Author(s): Mayee RV, Shinde PV.
The objective of this study was to develop and evaluate of Aceclofenac tablets with swelling and rupturable layers of ethyl cellulose. A tablet system consisting Intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis with a distinct predetermined lag time of 6 h. Cores containing Aceclofenac as model drug were prepared by direct compression of different Sodium starch glycolate level CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and were then coated sequentially with an inner swelling layer containing a superdisintegrant (croscarmellose sodium) and an outer rupturable layer of ethylcellulose. Seven formulations were prepared and formulation F2 possessed good lag time 6 hr and showed pulsatile drug delivery pattern the tablets In- vitro evaluation tests. Results of this study indicated that by using ethyl cellulose are suitable to optimize pulsatile drug release formulation of Aceclofenac.