Author(s): Harendra K. Sharma, Manoj Sharma
A simple, efficient and one pot microwave assisted synthesis of (5-amino-3-aryl-1H-pyrazol-1-yl) (6-chloropyrazin-2-yl) methanones is described. The molecules were synthesized by the cyclocondensation reaction of 6-chloropyrazine-2-carboxylic acid hydrazide and substituted benzoylacetonitriles by irradiation under microwave energy, to provide in high yields with clean and scalable reactions. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral data. The plausible mechanism of the reaction is proposed.