The purpose of this research is to know the comparison of duties, functions and authorities of KPPU in Indonesia with Federal Trade Commission (FTC) in the United States in handling monopolistic practices and unfair business competition. KPPU and Federal Trade Commission (FTC) are institutions that have authority in handling Business Competition cases. The difference between KPPU and FTC is on the scope of its authority. KPPU only has authority in law enforcement business competition while FCT not only has authority in business competition law enforcement; The FTC has another authority to protect the rights of consumers. Another difference between FTC and KPPU is that the FTC has the authority to conduct searches on cases handled, while KPPU does not have the independent authority to conduct searches in handling cases.